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It happens when a lot of sickled red blood cells get trapped in the spleen. The spleen can enlarge, get damaged, and not work as it should. When the spleen doesn't work well, a person is more likely to have serious, life-threatening infections with certain types of bacteria.
If splenic sequestration happens suddenly, it can be a life-threatening emergency.
This condition is more common in infants and young children who have sickle cell disease. It may follow a respiratory infection.
In older children and adults, the spleen often doesn't work because of years of damage from sickled cells.
Splenic sequestration causes sudden and severe anemia, with symptoms of sudden weakness, pale lips, rapid breathing, excessive thirst, belly pain, and rapid heartbeat. Splenic sequestration can happen in people who have sickle cell disease.
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